Intravenous Immunoglobulin in Autoimmune Neuromuscular Diseases

Intravenous immunoglobulin in autoimmune neuromuscular diseases.

CONTEXT Intravenous immunoglobulin (IVIG) enhances immune homeostasis by modulating expression and function of Fc receptors, interfering with activation of complement and production of cytokines, providing anti-idiotypic antibodies, and affecting the activation and effector functions of T and B cells. These mechanisms may explain the effectiveness of IVIG in autoimmune neuromuscular disorders. ...

Immunomodulating effects of intravenous immunoglobulin in autoimmune and inflammatory diseases.

Intravenous immunoglobulin (IVIg) therapy is increasingly used for its immunomodulating properties in a wide range of pathological conditions including autoimmune diseases, systemic inflammatory diseases and allotransplantation. Intravenous immunoglobulins are obtained from a pool of several thousand healthy blood donors. They are composed of intact IgG with a distribution of subclasses corresp...

Intravenous Immunoglobulin Therapy in Neurological Diseases

Intravenous immunoglobulin (IVIg) is used to treat a number of immune deficiencies and autoimmune diseases. The pharmacokinetic proprieties of IVIg in healthy persons are well defined. The broad range of clinical applications of IVIg shows the importance of immunoglobulins in the immune homeostasis in healthy people. Intravenous immunoglobulin (IVIg) is an immunomodulating agent that has multip...

Intravenous immunoglobulin treatment in neurological diseases.

INTRAVENOUS IMMUNOGLOBULIN (IVIg) IN AUTOIMMUNE DISEASES – EXPANDING INDICATIONS AND INCREASING SPECIFICITY

Even though intravenous immunoglobulin (IVIg) was originally used for the correction of immunodeficiency states, in the recent years it is also used as an immunomodulating agent in several autoimmune diseases. The indications for IVIg use in autoimmunity progressively expand and might include for example systemic lupus erythematosus, autoimmune vasculitides, and antiphospholipid syndrome. Howev...